Publications
Presence of diabetes autoantigens in extracellular vesicles derived from human islets.
Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S.
Sci Rep. 2017 Jul 10;7(1):5000.
PMID: 2869450
Assessment of Human Islet Grafts in Frozen Sections of CD-1 Athymic nu/nu Mouse Liver for Molecular Analysis
Hasilo CP, Negi S, Gasparrini M, Paraskevas S.
Transplant Proc. 2014 Jul-Aug;46(6):1956-9.
PMID: 25131081
GABA promotes human β-cell proliferation and modulates glucose homeostasis
Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang Z, Liang C, Shen E, Tadkase A, Feng ZP, Li Y, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M, Prud'homme GJ, Wang Q.
Diabetes. 2014 Jul 9.
PMID: 25008178
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N,
Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9.
PMID: 24395784
GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone
Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q.
Transplantation. 2013 Oct 15;96(7):616-23.
PMID: 23851932
Pancreas transplantation: in for the long run
Paraskevas S.
Curr Opin Organ Transplant. 2012 Feb;17(1):71-2.
PMID: 22227721
Evidence of endoplasmic reticulum stress mediating cell death in transplanted human islets
Negi S, Park SH, Jetha A, Aikin R, Tremblay M, Paraskevas S.
Cell Transplant. 2012;21(5):889-900.
PMID: 22182941
Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture
Negi S, Jetha A, Aikin R, Hasilo C, Sladek R, Paraskevas S.
PLoS One. 2012;7(1):e30415.
PMID: 22299040
Differential expression pattern of ZAC in developing mouse and human pancreas
Du X, Rousseau M, Ounissi-Benkalha H, Marchand L, Jetha A, Paraskevas S, Goodyer C, Polychronakos C.
J Mol Histol. 2011 Apr;42(2):129-36.
PMID: 21305342
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, Rosenberg L, Billestrup N, Maysinger D, Mandrup-Poulsen T.
Diabetes. 2009 Aug;58(8):1807-15.
PMID: 19470609
Transplantation for type 1 diabetes mellitus. Whole organ or islets?
Vrochides D, Paraskevas S, Papanikolaou V.
Hippokratia. 2009 Jan;13(1):6-8.
PMID: 19240814
Donor and isolation variables predicting human islet isolation success
Hanley SC, Paraskevas S, Rosenberg L.
Transplantation. 2008 Apr 15;85(7):950-5.
PMID: 18408573
Autocrine insulin action activates Akt and increases survival of isolated human islets
Aikin R, Hanley S, Maysinger D, Lipsett M, Castellarin M, Paraskevas S, Rosenberg L.
Diabetologia. 2006 Dec;49(12):2900-9.
PMID: 17053882
Tumor necrosis factor-alpha production by human islets leads to postisolation cell death
Hanley S, Liu S, Lipsett M, Castellarin M, Rosenberg L, Tchervenkov J, Paraskevas S.
Transplantation. 2006 Sep 27;82(6):813-8.
PMID: 17006329
Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans
Aikin R, Rosenberg L, Paraskevas S, Maysinger D.
J Mol Med (Berl). 2004 Jun;82(6):389-97.
PMID: 15105993
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody
Hering BJ, Kandaswamy R, Harmon JV, Ansite JD, Clemmings SM, Sakai T, Paraskevas S, Eckman PM, Sageshima J, Nakano M, Sawada T, Matsumoto I, Zhang HJ, Sutherland DE, Bluestone JA.
Am J Transplant. 2004 Mar;4(3):390-401.
PMID: 14961992
Signals for death and differentiation: a two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures
Jamal AM, Lipsett M, Hazrati A, Paraskevas S, Agapitos D, Maysinger D, Rosenberg L.
Cell Death Differ. 2003 Sep;10(9):987-96.
PMID: 12934073
Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal
Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Agapitos D, Wang R, Rosenberg L.
Ann Surg. 2001 Jan;233(1):124-33.
PMID: 11141234
Cell loss in isolated human islets occurs by apoptosis
Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L.
Pancreas. 2000 Apr;20(3):270-6.
PMID: 10766453
Structural and functional changes resulting from islet isolation lead to islet cell death
Rosenberg L, Wang R, Paraskevas S, Maysinger D.
Surgery. 1999 Aug;126(2):393-8.
PMID: 10455912
Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival
Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Hering B, Wang R, Rosenberg L.
FEBS Lett. 1999 Jul 23;455(3):203-8.
PMID: 10437773
Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas
Wang RN, Paraskevas S, Rosenberg L.
J Histochem Cytochem. 1999 Apr;47(4):499-506.
PMID: 10082751
Apoptosis occurs in freshly isolated human islets under standard culture conditions
Paraskevas S, Duguid WP, Maysinger D, Feldman L, Agapitos D, Rosenberg L.
Transplant Proc. 1997 Feb-Mar;29(1-2):750-2.
PMID: 9123509
Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture
Yuan S, Rosenberg L, Paraskevas S, Agapitos D, Duguid WP.
Differentiation. 1996 Oct;61(1):67-75.
PMID: 8921586
Phenotypic transformation of isolated human islets in collagen matrix culture
Yuan S, Paraskevas S, Duguid WP, Rosenberg L.
Transplant Proc. 1995 Dec;27(6):3364.
PMID: 8539996
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